Grow Youthful: How to Slow Your Aging and Enjoy Extraordinary Health
Grow Youthful: How to Slow Your Aging and Enjoy Extraordinary Health

Sjogren's syndrome

What is Sjogren's syndrome?

Symptoms of Sjogren's syndrome, consequences

Causes / triggers of Sjogren's syndrome

Remedies / treatment for Sjogren's syndrome

References

What is Sjogren's syndrome?

Sjogren's syndrome (SS) is a long-term autoimmune disease that affects the body's moisture-producing glands, the lacrimal and salivary glands. As it progresses, it often affects other organs including the lungs, kidneys and nervous system.

Sjogren's syndrome is a common rheumatic autoimmune disorder, only behind rheumatoid arthritis and systemic lupus erythematosus in frequency of occurrence. Between 2% and 6% of all adults are affected by SS, depending upon how it is defined and measured. There are no geographical differences in the rates of SS, but it affects women nine times more frequently than men.

Sjogren's syndrome has been diagnosed in all age groups, but the average age of onset is 40 to 60 years. The prevalence of SS increases with age.

SS is reported in 30-50% of people with rheumatoid arthritis and in 10-25% with systemic lupus erythematosus.

Symptoms of Sjogren's syndrome, consequences

Causes / triggers of Sjogren's syndrome

The medical establishment says that there is no known cause of SS, even though it is one of the most common autoimmune diseases. It has no specific diagnostic tests and treatment is directed at managing the patient's symptoms.

Remedies / treatment for Sjogren's syndrome

If you use any remedies from Grow Youthful, please come back next week (or whenever you have an outcome) and let us know about your experience. Please leave a comment as many people are interested.

See details of remedies recommended by Grow Youthful visitors, and their experience with them.

References

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2. Chen P, Tang X. Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis. Front Immunol. 2021 Dec 23;12:803101. doi: 10.3389/fimmu.2021.803101. PMID: 35003133; PMCID: PMC8732367.

3. Kong W, Yen JH, Ganea D. Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis. Brain Behav Immun. 2011 Jul;25(5):872-82. doi: 10.1016/j.bbi.2010.09.012. Epub 2010 Sep 18. PMID: 20854895; PMCID: PMC3031664.

4. Lee GR. The Balance of Th17 versus Treg Cells in Autoimmunity. Int J Mol Sci. 2018 Mar 3;19(3):730. doi: 10.3390/ijms19030730. PMID: 29510522; PMCID: PMC5877591.

5. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005 Jan 17;201(2):233-40. doi: 10.1084/jem.20041257. PMID: 15657292; PMCID: PMC2212798.

6. Chen Y, Tao T, Wang W, Yang B, Cha X. Dihydroartemisinin attenuated the symptoms of mice model of systemic lupus erythematosus by restoring the Treg/Th17 balance. Clin Exp Pharmacol Physiol. 2021 Apr;48(4):626-633. doi: 10.1111/1440-1681.13461. Epub 2021 Jan 19. PMID: 33469936.

7. Omenetti S, Pizarro TT. The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome. Front Immunol. 2015 Dec 17;6:639. doi: 10.3389/fimmu.2015.00639. PMID: 26734006; PMCID: PMC4681807.

8. Liang J, Jahraus B, Balta E, Ziegler JD, Hubner K, Blank N, Niesler B, Wabnitz GH, Samstag Y. Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione. Front Immunol. 2018 Nov 14;9:2584. doi: 10.3389/fimmu.2018.02584. PMID: 30487791; PMCID: PMC6246742.

9. Jaiboonma A, Kaokaen P, Chaicharoenaudomrung N, Kunhorm P, Janebodin K, Noisa P, Jitprasertwong P. Cordycepin attenuates Salivary Hypofunction through the Prevention of Oxidative Stress in Human Submandibular Gland Cells. Int J Med Sci. 2020 Jul 6;17(12):1733-1743. doi: 10.7150/ijms.46707. PMID: 32714076; PMCID: PMC7378660.

10. Ashraf SA, Elkhalifa AEO, Siddiqui AJ, Patel M, Awadelkareem AM, Snoussi M, Ashraf MS, Adnan M, Hadi S. Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic Potential. Molecules. 2020 Jun 12;25(12):2735. doi: 10.3390/molecules25122735. PMID: 32545666; PMCID: PMC7356751.